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Arsene Wenger will assess club-record signing Pierre-Emerick Aubameyang on Friday, with the forward having only just started training following a sickness bug.
But the Gunners boss revealed Henrikh Mkhitaryan will be handed his full debut against Everton after being introduced as a substitute in the 3-1 defeat to Swansea City.
The new additions bring some uncertainty as to how the Gunners could line up. If Wenger opts for a 4-2-3-1, Alexandre Lacazette may drop to the bench if Aubameyang is fit to start, unless the Arsenal boss uses either he or Aubameyang on the left wing.
Alex Iwobi has been favoured on the left of late, but could miss out. Presuming Mesut Ozil starts in his favoured No 10 role, that leaves only one of the wide spots for Mkhitaryan.
A 4-3-2-1 system could also be an option, however, with Ozil and Mkhitaryan both playing in central support roles behind Aubameyang.
Jack Wilshere missed out on Tuesday night due to illness, but providing he’s fit to return, he may replace Mohamed Elneny in central midfield.
Aaron Ramsey and Granit Xhaka could keep their places in the middle of the park, with Ramsey perhaps more at risk in a 4-2-3-1 if Wilshere is available.
Changes are unlikely in defence, with Nacho Monreal perhaps an option to move to the centre, which would allow either Ainsley Maitland-Niles or Sead Kolasinac to start at left-back.
Danny Welbeck (muscle injury) remains sidelined, while Santi Cazorla a long-term absentee.