Sead Kolasinac (thigh), Bukayo Saka (knock) and Reiss Nelson (hamstring) were all passed fit by Arsenal on Friday, with Kolasinac potentially in line to displace Saka at left-back as he had done at the start of the calendar year.
Lucas Torreira could find himself back in the centre of midfield if Matteo Guendouzi makes way, with the lesser-used Dani Ceballos struggling to get a look-in under Mikel Arteta.
Gabriel Martinelli looked less effective on the right flank against Burnley than he had on the opposite wing of late but it’s difficult to see Pierre-Emerick Aubameyang making way from that position, unless of course the Gabon international is moved centrally at the expense of Alexandre Lacazette.
Nicolas Pepe perhaps hasn’t quite won over his new manager yet given how in and out he has been in the Gunners’ side but is nevertheless a more natural fit on the right wing, with Joe Willock an alternative to Mesut Ozil in the hole.
Shkodran Mustafi’s surprisingly good form could see him continue alongside David Luiz, while Hector Bellerin has seen off the challenge of Ainsley Maitland-Niles in the last three matches in league and cup and may now have the edge at right-back.
Cedric Soares (knee), Kieran Tierney (shoulder) and Calum Chambers (knee) remain out, while Pablo Mari is aiming to feature against Olympiacos next Thursday as he builds up match-fitness.
Predicted Lineup: 4-2-3-1
Leno; Bellerin, Mustafi, Luiz, Kolasinac; Torreira, Xhaka; Pepe, Ozil, Aubameyang; Lacazette.