Arsenal’s hopes of finishing in the top four suffered a blow when they were beaten 3-2 at home by Crystal Palace on Sunday.
Christian Benteke, Wilfried Zaha and James McArthur all found the net for the Eagles, as defender Shkodran Mustafi produced a string of mistakes on a day to forget.
Mesut Ozil and Pierre-Emerick Aubameyang replied for the Gunners, but they never looked like pulling off any kind of rescue act.
“It was very frustrating because it was a big opportunity,” said Unai Emery.
“I still have confidence, though, and I want to be positive. We have to stand up and prepare for the trip to Wolves.”
Arsenal did manage to win their last away game against Napoli in the Europa League and before that prevailed 1-0 at Watford in this competition.
However, they were far from convincing versus a Hornets outfit reduced to 10 men early on and have suffered seven away defeats since mid-December.
Last Arsenal line-up: Leno, Koscielny, Mustafi, Jenkinson, Mavropanos, Kolasinac, Elneny, Ozil, Guendouzi, Lacazette, Aubameyang.
Arsenal will hope to have Granit Xhaka available after a hip injury and Sokratis Papastathopoulos returns following a two-match ban.
Barcelona loanee Denis Suarez (groin) remains sidelined, as does Aaron Ramsey (hamstring), as well as long-term absentees Danny Welbeck (ankle), Hector Bellerin and Rob Holding (both knee).
Here is how we expect the boss to line-up his side tonight…