The Gunners will hope their attacking talents come to the fore in Naples where a goal could all-but secure their place in the last four.
And their task will be made more difficult at a hostile San Paolo Stadium where the boisterous Napoli fans are close to the pitch, producing an atmosphere which Arsenal teams have struggled to deal with in recent years.
That record has continued in this season’s Europa League too, where they fell to 1-0 and 3-1 defeats at BATE Borisov and Rennes in the last two knockout rounds respectively, before turning the tie on its head at the Emirates.
Arsenal may have the goalscoring prowess of Pierre-Emerick Aubameyang and Alexandre Lacazette, but the former has yet to score away from home in all competitions since the turn of the year, while the latter has one goal on his travels since October.
Five defeats in their last seven away games does not improve their chances and just three triumphs on the road in 2019, at third-tier Blackpool, Huddersfield and more recently Watford, means it could be a tough evening for the Gunners.
Here is how we expect Emery to lineup his side against Ancelotti’s Napoli side.