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Aaron Ramsey was one of our standout performers at St Mary’s on Sunday and forced Fraser Forster into a world-class save in the first half.
But the Wales midfielder ended the game in pain – and unable to run – after picking up an injury in the second half.
“He has a hamstring problem,” Arsene Wenger told Arsenal.com.
“In the last 10 or 12 minutes if we had him fully fit it would have helped. That’s why it’s sometimes a big gamble when you [make substitutions] early.”
Ramsey will join Mustafi on the sidelines as Arsenal set to take on West Ham in a crucial London derby.