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Alexandre Lacazette has been ruled out of the home clash against Manchester United due to a groin injury picked up in the 5-0 win over Huddersfield Town in midweek.
Alexis Sanchez was taken off as a precaution against the Terriers with a minor hamstring problem but Arsene Wenger expects the Chilean to be available.
Sanchez, Olivier Giroud or Danny Welbeck could start as the lone striker – indeed, Welbeck has started all three league matches he has been available for against his former club.
Along with Alex Iwobi, he also offers an option alongside Mesut Ozil if Sanchez is shifted up front. The rest of the side could stay unchanged.
Granit Xhaka and Aaron Ramsey should both continue in central midfield, leaving Hector Bellerin and Sead Kolasinac in the wing-back positions and a settled back-three of Shkodran Mustafi, Laurent Koscielny and Nacho Monreal.
Theo Walcott (illness) is expected to be available, while Santi Cazorla is a long-term absentee.